CORNEVA CLINIC
You have a whole team. And somehow, your hormones are still no one's job.
Precision perimenopause care - designed for women with immune complexity, by the physician who understands both.
You are not imagining it. You are not too complicated. You have built a care team with skill and persistence - an immunologist, a rheumatologist, a cardiologist, a neurologist, a physical therapist, each managing their piece with care and competence. But in the complexity of everything else, the hormonal layer keeps getting pushed to next time.
Corneva exists because next time never comes.
And because the one missing piece - managed precisely, with full understanding of your immune picture - changes everything else.
Telehealth | Cash-Pay | Virginia - Maryland - DC - Expanding
YOU KNOW EXACTLY WHO YOU ARE
She has done more research on her own conditions than most of the physicians she has seen.
She is in her 40s or early 50s. She is educated, accomplished, and medically fluent. She manages her complex immune system including dysregulation, dysfunction, autoimmunity and other associated conditions, in combinations that exhaust less experienced clinicians. She has spent years navigating a system that was not built for her complexity, and has learned to advocate for herself because no one else connects the whole picture. What she has not been able to get - despite the team, despite the research, despite the persistence - is this.
This is why Corneva exists.
what she has been told
"Your labs are normal."
"This is probably anxiety."
"You're too complex for my practice."
"We'll address the hormonal piece at your next visit."
"That's just normal for your age."
"There's nothing else I can do for you here."
what she has never been told
"Here is someone who manages your hormones the way your body actually works."
"Your complexity is not an obstacle. It is exactly who this practice was built for."
"The hormonal and immune pieces of what you're experiencing are connected."
"You don't have to explain yourself again. We've read your history."
“Someone finally built this for me.”
THE GAP NO ONE TALKS ABOUT
Your immunologist knows your immune system. Your gynecologist knows your hormones. No one has ever been asked to know both.
Not because any one specialist is failing you. Because no one has ever been asked to hold both pictures at once - the immune complexity and the hormonal shifts happening underneath it. The hormonal piece gets noted. It gets deferred. It gets added to a list that never gets shorter. Meanwhile, unmanaged perimenopause is quietly making everything else harder.
Fatigue deepens - not because you aren't trying, but because estrogen does more for energy regulation than most physicians explain. Sleep deteriorates in ways that compound mast cell activation. The joint pain that appeared at 47 has estrogen in the story. The anxiety your doctor keeps noting? Estrogen does more for neurological stability than most clinical training covers. The immune-hormonal connection is not hypothetical. It is physiology. And managing it changes outcomes across your entire care team.
EXTERNAL PROBLEM
No one on your care team is managing your hormonal health.
Not because it's unimportant - because every appointment is already full. The structural reality of complex care means the hormonal piece always loses to whatever is most acute. This is a systems failure. Not a personal one. Not your specialists' failure. The system was never designed to hold this many pieces at once.
INTERNAL PROBLEM
You are exhausted by having to fight for every diagnosis.
You have done the research. You have come to appointments prepared and been dismissed anyway. You want a physician who meets you where you are - who reads your complexity as a clinical reality, not a clinical problem. You want to be understood, not accommodated. You are done starting from scratch.
PHILOSOPHICAL PROBLEM
A woman with immune complexity deserves perimenopause care built around how her body actually works.
The absence of this kind of care is a gap in medicine, not in her. She is not too complex to treat. The system never built a specialist who can hold the hormonal and immunological picture simultaneously. Until now, that specialist did not exist in this region. Corneva exists to close that gap specifically.
Women with immune dysregulation, chronic mast cell activation and autoimmunity experience perimenopause differently. The interplay between hormones, immune regulation and the menopausal transition is established physiology. Managing it changes outcomes.
MEET YOUR GUIDE
Founded by the physician who spent two decades watching this gap - and she decided she had seen enough of it.
Karen Kaufman, DO FAAAAI, is double board-certified in Allergy Immunology and Internal Medicine - the subspecialist who understands what happens inside the immune system when estrogen begins to fluctuate. She has spent her career at the intersection of immune complexity and precision medicine: the immune dysregulation, the mast cell activation, the autoimmune conditions that intensify as women enter midlife.
She saw these patients. She knew what was missing from their care. And she noticed, year after year, that no one was building the practice that could finally provide it.
So she built it herself.
Corneva is not designed to replace the specialists you have assembled with such effort. It is designed to complete what they cannot provide - the precision hormonal management informed by your full immune picture. The piece that has always been essential. The piece that has always been nobody's job, finally belongs to Corneva.
As Medical Director and immunologist, Dr. Kaufman doesn't see patients directly in Corneva, and that's intentional. She oversees every case from the immunologist's perspective, setting the clinical standard the practice runs on and making sure your hormonal plan is never separated from your immune picture. Corneva was designed as a two-physician model from day one: her expertise guiding the framework, another physician delivering your care within it.
Not because any one specialist is failing you. Because no one has ever been asked to hold both pictures at once - the immune complexity and the hormonal shifts happening underneath it. The hormonal piece gets noted. It gets deferred. It gets added to a list that never gets shorter. Meanwhile, unmanaged perimenopause is quietly making everything else harder.
Northern Virginia, Washingtonian, Arlington Magazines • Top Doctor
Washingtonian Magazine Face of Allergy & Immunology
Inc. Regionals Mid Atlantic • No.88 Fastest Growing Company 2026
DOUBLE BOARD CERTIFIED IN ALLERGY IMMUNOLOGY + INTERNAL MEDICINE
FELLOW, AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY
founder OF kaufman allergy asthma and immunology
COMING SOON
Your Treating Physician
The other half of your care team, announced soon. Corneva was built around two physicians from the start — Dr. Kaufman overseeing the immune picture, and a dedicated physician delivering your hormonal care day to day. We're hiring for that role now, and will introduce her here the moment it's filled.
"We believe your complexity is not a burden to be managed. It is the precise reason this practice exists."
– karen kaufman, DO FAAAAI • founder & medical director
how corneva works
Three steps to the piece that has always been missing.
Most practices ask you to start from scratch. Corneva is designed for someone who cannot afford to. Your history is complex and hard-won. Your time is limited. Your patience for re-explaining to a physician who has not read your chart has run out. We are aware of that before you arrive.
01
Your Consultation - We read what you've already built.
We begin with a comprehensive intake that actually reviews your history - your diagnoses, your specialist team, your current medications, your symptom patterns across time. You will not spend your first appointment re-explaining your complexity from scratch. We have done that work before the consultation begins. What you get is a conversation between clinical equals - focused on what comes next, no on what has already been established.
02
Your Precision Care Plan - Built for how your body actually works.
We review your full picture - hormonal, immunological, and the lived experience you bring - and build a hormonal health strategy informed by your immune profile. Not a standard perimenopause protocol. Not a one-size approach adapted for complexity. A plan built from the ground up for someone whose immune system responds to estrogen the way yours does.
03
Your Ongoing Partnership - The hormonal piece, finally tended.
Corneva is a long-term clinical relationship, not a one-time consultation. As your hormonal health evolves through the perimenopause transition, your care evolves with it - in active coordination with your existing specialist team. We communicate with your providers. We adjust as your picture changes. We hold the piece that has always fallen between appointments.
Telehealth • Cash-Pay • Outside of Insurance • DC, Virginia, Maryland at Launch • Multi-State Expansion Underway • Transparent Pricing Available Before You Book
What changes when the hormonal piece is managed
Not a transformation. A return to function.
This is not a promise of radiant wellbeing. It is a clinical reality: when perimenopause is managed in the context of immune complexity, other systems stabilize. The protocols you are already following work better. Your existing specialists begin to see results they couldn't achieve before. The baseline you have been working so hard to maintain stops requiring so much effort to maintain.
when this improves
this changes across your care
Fatigue decreases
More capacity for every other treatment protocol. Physical therapy becomes more productive. The daily energy cost of managing symptoms drops in ways that compound across your entire week.
Inflammation decreases
Estrogen's anti-inflammatory properties reduce immune-driven inflammation. Flares of mast cell activation become less frequent and less severe. The autoimmune activity that intensifies without estrogen support stabilizes.
Sleep stabilizes
Mast cell activation worsens at night, and hormonal instability amplifies it significantly. Managing both systems together transforms sleep quality in ways that neighter specialist could achieve treating their piece alone.
Neurological stability improves
Estrogen's role in neurotransmitter regulation is significant and underappreciated. Hormonal stability reduces the neurological burden of immune dysregulation - often providing more relief than any psychiatric intervention attempted in isolation.
Pain decreases
The connective tissue, joint, and inflammatory pain that peaks in perimenopause responds to hormonal management. This is established science. It is treatable. It has simply been no one's job to address it in the context of your immune complexity - until now.
Cognitive clarity returns
The brain fog of perimenopause has estrogen, cortisol, and immune dysregulation in the story simultaneously. Managing the hormonal piece removes one major contributor - and the downstream effect on cognition is often the outcome patients notice most.
Every specialist on your care team benefits from what Corneva does.
THE WINDOW IS REAL
You have already waited through many next times.
The hormonal piece does not resolve on its own. Perimenopause is a transition - but without management, its effects on the immune system accumulate. Fatigue becomes the baseline. Sleep loss compounds inflammation. The window for optimal hormonal management is real, and it moves. Bone density responds to estrogen management. Cardiovascular risk is shaped by it. The cognitive clarity that feels elusive right now has estrogen in the story. Each year of unmanaged perimenopause is a year of compounding effects on systems that were already working hard.
BEGIN YOUR CARE
You are not too complex.
You are exactly who we built this for.
Corneva is a precision telehealth practice serving women in DC, Virginia, and Maryland - with multi-state expansion underway. Consultations are conducted via telehealth. The practice is cash-pay, outside of insurance with transparent pricing available before you book.
If you are ready to have the hormonal piece finally managed - with clinical understanding of your full immune picture, and in coordination with the team you have already built - we are ready to begin.
FOR REFERRING PHYSICIANS
We complete your most complex patients' care teams.
Corneva Clinic provides precision perimenopause and hormonal management for patients with underlying immune complexity - mast cell disorders, autoimmunity, immunodeficiency, and related diagnoses like POTS and EDS. We work alongside your existing specialist team, not instead of it. Coordination notes are available upon request. We communicate. We document. We hold the piece your practice cannot carry alone.
Corneva does not treat underlying immune or connective tissue conditions. Corneva provides perimenopause and hormonal health management informed by but clinically distinct from immune condition management.